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目的:探讨复方中药同步放化疗治疗直肠癌术后局部复发的疗效。方法:将40例直肠癌术后局部复发患者,随机分为治疗组和对照组各20例,所有患者均接受同步放化疗(三维适形放疗+替吉奥),治疗组在放化疗的同时同步服用复方中药,从放化疗开始连续用至治疗结束,对照组只行放化疗,治疗完成后评价两组患者疗效和毒副反应。结果:治疗组大于Ⅱ级的骨髓抑制、放射性直肠炎以及放射性膀胱炎等毒副反应的总发生率为10.0%,远低于对照组的30.0%,两组差异有统计学意义(P<0.05);与对照组比较,治疗组可以明显提高直肠癌术后复发患者的NK细胞及CD4/CD8(P<0.05)。结论:直肠癌术后局部复发应用复方中药联合放化疗可明显减轻放化疗的毒副反应,改善患者免疫功能。
Objective: To investigate the curative effect of compound Chinese medicine concurrent chemoradiotherapy on local recurrence of rectal cancer after operation. Methods: Forty patients with local recurrence after rectal cancer were randomly divided into treatment group and control group, 20 cases in each group. All patients underwent concurrent chemoradiotherapy (3D conformal radiotherapy + Simultaneous use of compound traditional Chinese medicine, from the beginning of radiotherapy and chemotherapy to the end of treatment, the control group only chemoradiotherapy, after treatment, evaluation of the efficacy and toxicity of two groups of patients. Results: The total incidence of bone marrow suppression, radiation proctitis and radiation cystitis in the treatment group was 10.0%, which was significantly lower than that in the control group (30.0%, P <0.05) ); Compared with the control group, the treatment group can significantly improve the NK cells and CD4 / CD8 (P <0.05) in patients with recurrent rectal cancer postoperative recurrence. Conclusion: The local recurrence of rectal cancer with compound traditional Chinese medicine combined with radiotherapy and chemotherapy can significantly reduce the side effects of radiotherapy and chemotherapy, and improve immune function.