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[目的]探讨胺碘酮对阵发性心房颤动患者射频消融术后近远期复发情况及心房结构的影响.[方法]回顾性分析2012年12月至2014年12月本院收治的100例阵发性心房颤动患者的临床资料.所有患者均行射频消融术,根据术后用药方案的不同将其分为对照组(常规治疗+氯沙坦,n=50)和观察组(在对照组的基础上加用胺碘酮,n=50).比较两组术后1周、1个月、3个月、12个月、18个月复发情况;比较两组术前、术后血清超敏C反应蛋白(hs-CRP)水平;比较左心房内径(LAD)、左心房容积(LAV).[结果]两组患者术后1周复发率比较,差异无统计学意义(P＞0.05);观察组术后1个月、3个月、12个月、18个月复发率均显著低于对照组,差异具有统计学意义(P＜0.05).观察组、对照组术后3个月、6个月血清hs-CRP水平显著高于术前,观察组术后3个月、6个月、18个月血清hs-CRP水平显著低于对照组,差异有统计学意义(P＜0.05).观察组术后6个月、12个月、18个月LAV显著低于术前,对照组术后18个月LAV显著低于术前,差异具有统计学意义(P＜0.05);观察组术后6个月、12个月、18个月LAD、LAV显著低于对照组,差异有统计学意义(P＜0.05).[结论]胺碘酮能够降低射频消融术后患者体内炎症反应,显著降低阵发性心房颤动射频消融术后的近远期复发率,同时能够降低左心房内径,改善患者心功能.“,”[Objective]To investigate the effect of amiodarone on the recurrence and atrial structure in patients with paroxysmal atrial fibrillation after radiofrequency ablation.[Methods]The clinical data of 100 patients with paroxysmal atrial fibrillation admitted in our hospital from December 2012 to December 2014 were retrospectively analyzed.All patients were treated with radiofrequency ablation and were divided into two groups:control group (routine treatment +-losartan,n=50) and observation group (treated with amiodarone on the basis of the control group).The recurrence after operation was compared between the two groups 1 week,1 month,3 months,12 months,18 months after treatment.The levels of serum hs-CRP were compared between the two groups before and after operation.The left atrial internal diameter (LAD) and the left atrial volume (LAV) were also compared.[Results]There was no significant difference in recurrence rate between the two groups at 1 week postoperatively (P ＞0.05).The recurrence rate at 1 month,3 months,12 months and 18 months after operation in the observation group was significantly lower than that in the control group,the difference was statistically significant(P ＜ 0.05).The serum hs-CRP levels in the observation group and the control group were significantly higher than those before operation at 3 months and 6 months after operation.The LAV in the control group was significantly lower than that before operation 18 months after operation,the difference was statistically significant (P ＜0.05).6 months,12 months and 18 months after operation,LAD and LAV in the observation group was significantly low-er than that in the control group,the difference was statistically significant (P ＜0.05).[Conclusion]Amiodarone can reduce the inflammatory response in patients after radiofrequency ablation,and significantly reduce the shortterm and long-term recurrence rate of paroxysmal atrial fibrillation after radiofrequency ablation.At the same time,it can reduce left atrial diameter and improve cardiac function.