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目的 为探讨原发性胃肠道非何杰金淋巴瘤 (NHL)临床诊治和预后经验 .方法 回顾性分析我院 1978/ 1999年手术治疗的 NHL 41例 .结果 胃 14例 ,小肠 11例 ,结肠 16例 .B超、CT和胃肠造影阳性率分别为 82 % ,76 %和 83% ;内窥镜活检确诊率 93% .临床分期 E期 14例 , E期 2 7例 .组织分类低度恶性 2 8例 ,中度恶性 12例 ,高度恶性 1例 .胃、小肠和结肠肿瘤手术切除依次为 10 0 % ,91%和 89% .单纯手术 14例 ,术后化疗 2 7例 . 1,3和 5 a生存率分别为 95 % ,76 %和 6 3% .肿瘤大小、组织分类、临床分期和术后化疗不同 ,其预后差异显著 (P<0 .0 1,P<0 .0 1,P<0 .0 5和 P <0 .0 1) .结论 1内窥镜活检对本病具有较高的确诊价值 ;2对于早期局限性胃肠道 NHL 首选手术治疗 ,而术后化疗对于预防肿瘤的复发可能起一定作用 ;3患者预后可能与肿瘤大小、组织分类、临床分期和术后化疗有关
Objective To investigate the clinical diagnosis, treatment and prognosis of primary gastrointestinal non-Hodgkin’s lymphoma (NHL). Methods Retrospective analysis of 41 cases of NHL surgically treated in our hospital in 1978/1999. Result: 14 cases of stomach, 11 cases of small intestine, The positive rates of B-ultrasonography, CT, and gastrointestinal angiography were 82%, 76%, and 83%, respectively. The final diagnosis rate of endoscopic biopsy was 93%. There were 14 cases of clinical stage E and 27 cases of E stage. Degree of malignancy in 28 cases, 12 cases of moderate malignancy, 1 case of high-grade malignancy. Surgical resection of gastric, small intestine and colon tumors were 10%, 91% and 89%, respectively. 14 cases of surgery alone, postoperative chemotherapy in 27 cases. 1 The 3, 5 and 5-year survival rates were 95%, 76%, and 63%, respectively. Tumor size, tissue classification, clinical stage, and postoperative chemotherapy were significantly different (P < 0.01, P <0. 1. P<0.05 and P<0.01). Conclusion 1 Endoscopic biopsy has a higher definite diagnosis value for this disease; 2 For the early limited gastrointestinal tract NHL preferred surgical treatment, and postoperative chemotherapy For the prevention of tumor recurrence may play a role; 3 prognosis may be related to tumor size, tissue classification, clinical staging and postoperative chemotherapy