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目的研究宣威、昆明两地非小细胞肺癌患者P16蛋白表达的差异性,探讨P16蛋白在肺癌发生发展中的作用。方法采用免疫组化对宣威、昆明地区非小细胞肺癌各45例和非肺癌(肺大疱、肺出血)行手术切除的正常肺组织石蜡包埋标本18例进行P16蛋白表达检测。结果 P16蛋白免疫组化阴性表达共有45例,总失活率为41.7%,其中宣威肺癌组、昆明肺癌组、对照组的失活率分别为57.8%、37.8%、11.1%。两肺癌组P16蛋白失活率分别与对照组的差异有统计学意义(P<0.05);两肺癌组P16蛋白的总失活率差异无显著性(P=0.058);宣威肺癌组在Ⅰ期、T2期和腺癌的失活率比昆明肺癌组高(P<0.05)。结论与昆明肺癌组相比,宣威肺癌组P16蛋白不表达率在肺癌早期和腺癌中呈高表达。
Objective To investigate the difference of P16 protein expression between non-small cell lung cancer patients in Xuanwei and Kunming and to explore the role of P16 in the development and progression of lung cancer. Methods Immunohistochemistry was used to detect the expression of P16 protein in paraffin-embedded specimens of normal lung tissues from 45 cases of non-small cell lung cancer and non-lung cancer (bullae and pulmonary hemorrhage) in Xuanwei and Kunming. Results There were 45 cases with negative expression of P16 protein, with a total inactivation rate of 41.7%. The inactivation rates of Xuanwei lung cancer group, Kunming lung cancer group and control group were 57.8%, 37.8% and 11.1% respectively. There was no significant difference in the total inactivation rate of P16 protein between the two lung cancer groups (P <0.05) Stage, T2 and adenocarcinoma inactivation rate than Kunming lung cancer group (P <0.05). Conclusions Compared with Kunming lung cancer group, the non-expression of P16 protein in Xuanwei lung cancer group is highly expressed in early lung cancer and adenocarcinoma.