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1944年,Eaton等从1例冷凝集试验阳性的原发性非典型肺炎病人的痰中分离到一种滤过因子,当时暂归为病毒类,以后被称为伊顿因子。1957年,Liu使用间接免疫荧光法见到鸡胚支气管上皮内的伊顿因子。又经4年,Marmion等发现该微生物可被金盐抑制而知是胸膜肺炎样微生物(PPLO)。1962年,Chanock等把伊顿因子在人工培养基上接种成功,并根据菌落形态、染色特点以及对血清的要求,认为它与1898年Nocard等首先发现的牛胸膜肺炎样微生物类似,鉴定为支原体(Mycoplasma)
In 1944, Eaton et al. Isolated a filtration factor from the sputum of a patient with SARS positive for agglutination test, which was temporarily classified as a virus and was later referred to as Eaton. In 1957, Liu used indirect immunofluorescence to see the Eaton factor in the chicken embryo bronchial epithelium. After another four years, Marmion et al. Found that this microorganism can be inhibited by gold salts and is known as pleuropneumoniae-like microorganism (PPLO). In 1962, Chanock et al. Successfully inoculated Eaton on artificial media and considered it to be mycoplasma (Mycoplasma pneumoniae) in accordance with the colony morphology, staining characteristics, and serum requirements Mycoplasma)