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目的观察卡介菌多糖核酸辅助治疗复治涂阳肺结核患者疗效。方法随机将2003—2005年吉林省前郭县结核病防治所60例复治涂阳肺结核患者分为治疗组和对照组,每组30例,两组使用相同的化疗方案即2S3H3R3E3Z3/6H3R3E3,治疗组在化疗基础上,加用卡介菌多糖核酸,对照组,单用化疗药物。结果治疗组,满2月痰菌阴转率93.3%,治愈率86.6%。对照组满2月痰菌阴转率83.3%。治愈率66.6%,经统计学处理(P<0.05)差异显著。结论卡介菌多糖核酸辅助治疗复治涂阳肺结核患者,是较好的免疫增强剂。
Objective To observe the curative effect of BCG-polysaccharide nucleic acid adjuvant therapy on smear-positive pulmonary tuberculosis patients. Methods A total of 60 patients with retreatment and smear positive pulmonary tuberculosis in Qian Guo County TB Hospital of Jilin Province during 2003-2005 were randomly divided into treatment group and control group, with 30 patients in each group. The two groups were treated with the same chemotherapy regimen, namely 2S3H3R3E3Z3 / 6H3R3E3. On the basis of chemotherapy, plus BCG polysaccharide nucleic acid, control group, chemotherapy alone. Results In the treatment group, the sputum negative conversion rate was 93.3% in February and the cure rate was 86.6%. The control group in February sputum negative conversion rate of 83.3%. The cure rate was 66.6%, which was statistically significant (P <0.05). Conclusion BCG polysaccharide nucleic acid adjuvant treatment of smear-positive pulmonary tuberculosis patients is a better immune enhancer.