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乳腺癌是危害女性健康最主要的恶性肿瘤之一,其发病率总体呈上升趋势。乳腺癌的病因及其发病机制目前尚不完全清楚,其病理类型和基因表达在不同个体异质性较大,对治疗的应答也各不相同,这些问题已成为乳腺癌基础与临床研究的热点。微小RNAs(mi RNAs)是一类广泛存在于真核细胞中的长约18~22 nt的单链、非蛋白编码RNA,具有转录后基因调控的功能,能够调节细胞增殖、凋亡以及分化等多种生物学过程。其中mi R-21在诱导细胞的增殖与
Breast cancer is one of the most important malignant tumors that endanger the health of women, and its incidence is generally on the rise. The etiology and pathogenesis of breast cancer is not yet fully understood, the pathological types and gene expression in different individuals heterogeneity, the response to treatment are also different, these problems have become the hot spots of basic and clinical research of breast cancer . MicroRNAs (miRNAs) are a class of single-stranded, non-coding RNAs that are about 18 to 22 nt in length and exist in eukaryotic cells. They have the function of post-transcriptional gene regulation, which can regulate cell proliferation, apoptosis and differentiation A variety of biological processes. Among them mi R-21 in inducing cell proliferation and