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目的 为临床局部应用消痔灵注射液治疗胃癌提供实验依据 .方法 应用体外试验 (MTT法 )和体内试验 (裸鼠人胃癌 SGC- 790 1模型 )观察消痔灵注射液的抗胃癌作用 .结果 消痔灵注射液对人胃癌细胞的体外杀伤率为 6 0 .5 %(P<0 .0 1) ,瘤体内注射消痔灵对人胃癌的抑瘤率为 43.5 %(P<0 .0 5 ) ,消痔灵注射液不仅使肿瘤血管栓塞、缺血坏死 ,而且可进入肿瘤细胞起直接杀伤作用 .结论 消痔灵注射液局部应用对人胃癌有较强的抗癌作用 ,可能成为一种新型局部抗胃癌药物 .
Objective To provide experimental evidence for clinical application of Xiaozhiling injection in the treatment of gastric cancer.Methods The anti-gastric cancer effect of Xiaozhiling injection was observed by in vitro test (MTT method) and in vivo test (SGC-7901 model of human gastric cancer in nude mice) .Results Xiaozhiling injection on human gastric cancer cells in vitro killing rate was 6.5% (P <0.01), the injection of Xiaozhiling on human gastric cancer inhibition rate was 43.5% (P <0. 0 5), Xiaozhiling injection not only embolization of tumor vessels, ischemia and necrosis, and can directly enter the tumor cells killing effect.Conclusion Xiaozhiling injection topical application of human gastric cancer has a strong anti-cancer effect, may become a A new type of local anti-cancer drugs.