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目的探讨毛细支气管炎患儿血清可溶性细胞间粘附分子1(sICAM-1)、嗜酸细胞趋化因子(Eotaxin)水平相关性及临床意义。方法毛细支气管炎患儿30例,采用双抗体夹心酶联免疫吸附试验(ELISA)测定其血清sICAM-1、Eotaxin水平,并比较其与高危因素的关系。结果毛细支气管炎患儿急性期血清sICAM-1、Eotaxin水平高于对照组(P<0.05),也高于恢复期(P<0.01);恢复期血清sICAM-1、Eotaxin与对照组差异没有统计学意义(P>0.05)。毛细支气管炎患儿血清中sICAM-1与Eotaxin含量之间存在正相关性。具有家族和/或个人过敏史者恢复期sICAM-1、Eotaxin血清水平高于无家族史和/或个人过敏史者(P<0.05)。肥胖患儿恢复期Eotaxin血清水平高于正常体重儿(P<0.05),市区及被动吸烟患儿恢复期sICAM-1血清水平高于农村及无被动吸烟者(P<0.05)。结论sICAM-1、Eotaxin参与小儿毛细支气管炎的病理过程。家族史、个人过敏史、肥胖、环境影响等相关因素可能导致毛细支气管炎反复发作。
Objective To investigate the correlation and clinical significance of serum soluble intercellular adhesion molecule 1 (sICAM-1) and eotaxin in children with bronchiolitis. Methods Thirty patients with bronchiolitis were enrolled in this study. Serum levels of sICAM-1 and Eotaxin were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA), and their relationship with risk factors was compared. Results Serum levels of sICAM-1 and Eotaxin in children with bronchiolitis were significantly higher than those in the control group (P <0.05), and also higher than those in the recovery group (P <0.01). There was no statistical difference in the serum levels of sICAM-1 and Eotaxin Significance (P> 0.05). There was a positive correlation between serum sICAM-1 and Eotaxin levels in children with bronchiolitis. Patients with family and / or individual allergies had higher recovery of sICAM-1 and Eotaxin serum levels than those with no family history and / or personal allergies (P <0.05). Serum levels of Eotaxin in obese children during recovery were higher than those in normal weight children (P <0.05). Serum levels of sICAM-1 in urban and passive smoking children were higher than those in rural and non-passive smokers (P <0.05). Conclusion sICAM-1, Eotaxin participate in the pathogenesis of pediatric bronchiolitis. Family history, personal allergies, obesity, environmental impact and other related factors may lead to recurrent bronchiolitis.