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目的:探讨卡前列素氨丁三醇联合卡孕栓预防剖宫产产后出血的临床疗效。方法:回顾性分析2015年6月至2016年6月龙川县妇幼保健院确诊治疗的剖宫产患者120例,依据治疗方法分为卡前孕栓组和卡孕栓组,每组60例,卡孕栓组患者给予舌下含服卡孕栓治疗,卡前孕栓组患者在此基础上于胎儿娩出后子子宫肌肌注卡前列素氨丁三醇治疗,分析患者术中、术后出血和不良反应发生情况。结果:卡前孕栓组患者术中、术后2 h、24 h的出血量明显低于卡孕栓组,前者产后出血率明显低于后者,差异具有统计学意义(P<0.05);卡前孕栓组和卡孕栓组患者不良反应发生率基本相同,差异无统计学意义(P>0.05)。结论:卡前列素氨丁三醇联合卡孕栓治疗可有效减少剖宫产患者术中和术后出血,有利于预防产后出血的发生,且无增加患者不良反应发生的风险。
Objective: To investigate the clinical effect of carboprost trometamol combined with carbamazepine in preventing bleeding after cesarean section. Methods: A retrospective analysis of 120 cases of cesarean section diagnosed and treated in Longchuan County Maternal and Child Health Hospital from June 2015 to June 2016 was divided into pre-card progestational suppository group and carbamazepine group, with 60 cases in each group , Patients in the subgroups of caesar suppository received sublingual subconjunctival injection of maternal suppository, and patients in the premenstrual cardiotomy group received suboptimal hormone therapy of methotrexate trometamol after the delivery of the fetus. Analysis of intraoperative and surgical Post-bleeding and adverse reactions occurred. Results: The amount of bleeding at 2 h and 24 h after operation was significantly lower in patients with premenstrual suppository than those in control group. The rate of postpartum hemorrhage in the former group was significantly lower than that in the latter (P <0.05). The incidence of adverse reactions in the patients with premenstrual suppository and carbamazepine groups were basically the same, with no significant difference (P> 0.05). CONCLUSION: The combination of carboprost plus trichostatin can effectively reduce the intraoperative and postoperative bleeding in patients with cesarean section and prevent the occurrence of postpartum hemorrhage without increasing the risk of adverse reactions.