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目的探讨T淋巴细胞亚群在恶性肿瘤患者中的预测价值。方法选取福建省泉州市第一医院2015年1月—2016年4月收治的恶性肿瘤患者80例作为研究组,另选择本院同期进行健康体检患者80例作为对照组。测定比较两组患者T淋巴细胞亚群(CD_3~+细胞分数、CD_4~+细胞分数、CD_8~+细胞分数),比较研究组不同肿瘤患者T淋巴细胞亚群水平及研究组中死亡患者与未死亡患者入院时T淋巴细胞亚群水平。结果研究组患者CD_3~+细胞分数、CD_4~+细胞分数低于对照组,CD_8~+细胞分数高于对照组(P<0.05)。研究组不同肿瘤患者T淋巴细胞亚群水平比较,差异无统计学意义(P>0.05)。死亡患者CD_3~+细胞分数、CD_4~+细胞分数低于未死亡患者,CD_8~+细胞分数高于未死亡患者(P<0.05)。结论 T淋巴细胞亚群对于判断恶性肿瘤患者免疫水平、分析患者预后具有重要价值。
Objective To investigate the predictive value of T lymphocyte subsets in patients with malignant tumors. Methods Eighty patients with malignant tumors admitted to the First Hospital of Quanzhou, Fujian Province from January 2015 to April 2016 were selected as the study group, and another 80 healthy patients were selected as the control group in the same period. T lymphocyte subsets (CD_3 ~ + cell fraction, CD_4 ~ + cell fraction, CD_8 ~ + cell fraction) of two groups were measured and compared. The levels of T lymphocyte subsets in different tumor groups were compared with those in the study group T Lymphocyte subsets on admission to hospital. Results The scores of CD_3 ~ + cells, CD_4 ~ + cells in the study group were lower than those in the control group, and the scores of CD_8 ~ + cells were higher than those in the control group (P <0.05). There was no significant difference in the levels of T lymphocyte subsets among different cancer patients in the study group (P> 0.05). The percentage of CD_3 ~ + cells and CD_4 ~ + cells in patients who died were lower than those who did not. The percentage of CD_8 ~ + cells was higher than those who did not (P <0.05). Conclusion T lymphocyte subsets have important value in judging the immune status of patients with malignant tumors and analyzing the prognosis of patients.