二甲基亚砜被广泛应用于生物、化学和药学领域,这些应用大多与其增加生物膜的通透性、促进活性分子跨膜传输的作用密切相关。本文对二甲基亚砜增加生物膜通透性的理论及实验研究做简要综述,主要强调二甲基亚砜在生物膜中诱导水性孔道形成的分子动力学模拟及其相关的实验研究。 Dimethylsulfoxide is widely used in biological, chemical and pharmaceutical fields. Most of these applications are closely related to its ability to increase the permeability of biofilm and promote the transmembrane transport of active molecules. In this paper, we briefly reviewed the theoretical and experimental studies on the increase of biofilm permeability of dimethylsulfoxide (DMSO), focusing on the molecular dynamics simulations of dimethyl sulfoxide (DMSO) induced biofilm formation in biofilms and their related experimental studies.