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目的:探讨辅助生殖技术中中重度卵巢过度刺激综合征(OHSS)的临床特征、妊娠结局及预防方法。方法:回顾性分析同济医院生殖中心2005年5月～2008年5月期间行体外受精-胚胎移植(包括ICSI)中93例中重度OHSS的临床资料。结果:①尽管OHSS的发生与基础窦卵泡数目相关,但OHSS发生的程度与基础窦卵泡、Gn用量及采卵个数无相关性;②妊娠加重OHSS的病情,极重度OHSS的发生可能只与妊娠相关。③妊娠组患者采卵个数明显低于其他组,总病程、白蛋白用量明显高于其他组,发病时间明显晚于其他组。④对于OHSS的患者,冷冻所有胚胎以备复苏,并不降低妊娠率。结论:对OHSS高危患者应及早进行严密观察,采取适当的预防措施,以减少严重并发证的发生率。
Objective: To investigate the clinical features, pregnancy outcome and prevention of moderate to severe ovarian hyperstimulation syndrome (OHSS) in assisted reproductive technology. Methods: The clinical data of 93 patients with moderate-severe OHSS undergoing in vitro fertilization-embryo transfer (including ICSI) from May 2005 to May 2008 in Tongji Hospital Reproductive Center were retrospectively analyzed. Results: ① Although the incidence of OHSS was related to the number of basal antral follicles, the degree of occurrence of OHSS was not related to the number of basal antral follicles, Gn dosage and the number of eggs laid; ② The severity of OHSS in pregnancy increased, Pregnancy related. ③ The number of eggs laid in pregnancy group was significantly lower than the other groups, the total duration of disease, the amount of albumin was significantly higher than other groups, the onset time was significantly later than other groups. ④ For OHSS patients, freezing all embryos for recovery does not reduce the pregnancy rate. Conclusion: Patients with high-risk OHSS should be closely observed as soon as possible and appropriate preventive measures should be taken to reduce the incidence of serious and complicated card-issuing.