论文部分内容阅读
目的 探讨慢性肾功能衰竭 (CRF)患者甲状旁腺激素 (PTH)和甲状旁腺激素相关蛋白 (PTHr P)的关系。方法 采用放免法测定 92例 CRF患者和 30例正常人血清 PTH和血浆 PTHr P含量 ,并按 CRF分期 ,将 CRF患者分为四期。结果 (1 )在慢性肾功能衰竭各个阶段 ,血清 PTH、血浆 PTHr P含量较正常对照组明显升高 (P<0 .0 1 )。 (2 )相关分析显示血清 PTH与血肌酐 (Scr)、血尿素氮 (BUN)、碱性磷酸酶 (AL P)、血压 (BP)存在显著正相关 (P<0 .0 1 ) ,与血红蛋白 (Hb)存在显著负相关 ,与钙 (Ca)、磷 (P)无相关性 (P>0 .0 5)。血浆 PTHr P与Scr、 BUN存在显著正相关 (P<0 .0 1或 P<0 .0 5) ,与 Ca、 P、 Hb、 ALP、 BP无显著相关性 (P>0 .0 5)。两者与年龄、病程均无显著相关性 (P>0 .0 5)。结论 (1 )血清 PTH含量及血浆 PTHr P均可反映慢性肾功能衰竭的程度 ,其含量随肾功能损害的加重而逐渐升高。 (2 )血清 PTH含量及血浆 PTHr P反映肾功能损伤基本一致 ,但两者与 Ca、P、Hb、ALP、 BP相关性不完全相同
Objective To investigate the relationship between parathyroid hormone (PTH) and parathyroid hormone related protein (PTHr P) in patients with chronic renal failure (CRF). Methods The levels of serum PTH and PTHr P in 92 patients with CRF and 30 normal individuals were determined by radioimmunoassay. CRF patients were divided into four groups according to CRF classification. Results (1) The levels of serum PTH and plasma PTHr P in chronic renal failure were significantly higher than those in normal control group (P <0.01). (2) Correlation analysis showed that serum PTH was positively correlated with Scr, BUN, ALP and BP (P <0.01) (Hb), but no correlation with calcium (Ca) and phosphorus (P) (P> 0.05). Plasma PTHr P was positively correlated with Scr and BUN (P <0.01 or P <0.05), but not with Ca, P, Hb, ALP and BP (P> 0.05). There was no significant correlation between age and duration of disease (P> 0.05). Conclusions (1) Serum PTH levels and plasma PTHr can reflect the degree of chronic renal failure, the content increased with the increase of renal dysfunction and gradually increased. (2) Serum PTH levels and plasma PTHr reflect the basic renal injury, but the two with Ca, P, Hb, ALP, BP is not exactly the same