局部血管平滑肌细胞的大量增殖,在动脉硬化的形成上起重要作用。根据1976年Ross等倡导的应激学说认为:首先是机械的、化学的及免疫等刺激引起血管内皮细胞剥脱,继之在剥离部位发生血小板粘附凝集,从凝集的血小板释放血小板增殖因子(PDGF),促进中膜平滑肌细胞向内膜移动、增殖,如此反复进行而形成典型的动脉硬化。但是在高脂血症家兔动物试验时,发现在内皮细胞完整、血小板粘附以前,就已有单核细胞和巨噬细胞的皮下浸滑,从而认为在动脉硬化形成的早期,不一定非要有内皮细胞剥离及血小板粘附,而单核细胞和巨噬细胞向内皮下浸润却是最重要的。单核细胞和巨噬细胞主要是释放PDGF I型白细胞介素(IL-1)等各种生理活性物质、起初认为IL-1是淋巴细胞的分化和增殖因子,而现在确认其除作 The proliferation of local vascular smooth muscle cells plays an important role in the formation of arteriosclerosis. According to the stress theory advocated by Ross et al. In 1976, it is believed that the first is that mechanical, chemical and immune stimuli cause exfoliation of vascular endothelial cells followed by platelet adhesion and agglutination in exfoliated sites and release of platelet growth factor (PDGF) from aggregated platelets ), Promote smooth muscle cells in the tunica media to move intima, proliferation, so repeatedly formed typical atherosclerosis. However, in rabbits with hyperlipidemia, it has been found that subcutaneous immersion of monocytes and macrophages prior to endothelial cell integrity and platelet adhesion has led to the belief that it is not necessarily the early stage of atherosclerosis Endothelial cell detachment and platelet adhesion, while monocytes and macrophages subendothelial infiltration is the most important. Monocytes and macrophages mainly release a variety of physiologically active substances such as PDGF type I interleukin (IL-1). Initially, IL-1 was considered as a lymphocyte differentiation and proliferation factor,