论文部分内容阅读
目的探讨血管内皮生长因子(vascular Endothelial Growth Factor VEGF)和微血管密度(Microvessel Density MVD)在大肠癌组织中的表达与患者生存预后关系。方法收集1997~2007年收治生存期≥5年及≤3年大肠癌患者标本各30例,应用免疫组织化学(Envision)测定这60例大肠癌组织中VEGF和MVD表达,分析检测结果与临床病理特点及患者预后关系。结果≥5年30例大肠癌患者VEGF,MVD表达强度与≤3年30例大肠癌患者在浸润深度,TNM分期,淋巴结转移间比较,均有显著性差异(P<0.001),而性别,年龄,分化程度及病理分型差异性不显著(P>0.05),且VEGF与MVD表达两者呈正相关(r=0.974,,P<0.05)。结论 VEGF对大肠癌的生长和浸润转移有促进作用,VEGF和MVD可以作为判断大肠癌患者预后重要参考指标。
Objective To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and microvessel density (MVD) in colorectal carcinoma and the prognosis of patients. Methods Thirty cases of colorectal cancer patients with survival ≥ 5 years and ≤ 3 years were collected from 1997 to 2007. The expressions of VEGF and MVD in the 60 cases of colorectal carcinoma were detected by immunohistochemistry. The correlation between the detection results and clinical pathology Characteristics and prognosis of patients. Results The expression of VEGF and MVD in 30 cases of colorectal cancer ≥ 5 years was significantly different from that of 30 cases of colorectal cancer ≤ 3 years in the depth of invasion, TNM stage and lymph node metastasis (P <0.001), while the gender, age (P> 0.05). There was a positive correlation between the expression of VEGF and MVD (r = 0.974, P <0.05). Conclusion VEGF can promote the growth and infiltration and metastasis of colorectal cancer. VEGF and MVD can be used as important reference indexes for prognosis of patients with colorectal cancer.