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[目的]调查广州市女性乳腺癌的危险因素 ,为乳腺癌的防治提供依据。[方法]采用1∶1配对的病例对照研究方法 ,问卷调查1997年1至6月348例年龄范围在30岁～74岁、经病理组织学确诊的女性乳腺癌生存病例。调查内容包括一般情况、生活居住环境、饮食习惯、生活方式、疾病和家族史、女性生理与生育等6个方面的问题。用相对危险度的近似估计值比数比(Oddratio,OR)估计危险因子与乳腺癌的联系强度 ,用Logistic回归模型进行单因素和多因素分析筛选出有意义的危险因素。[结果]经多因素分析 ,与乳腺癌发病有关的变量为十年前鱼虾月均进食量大、缺乏体育锻炼、被动吸烟、精神压抑、月经不规律及生殖系统手术史(P<0.05) ,对乳腺癌有保护作用的变量为经常进食葱类食品和生育(P<0.05)。[结论]10年前鱼虾月均进食量大、缺乏体育锻炼、被动吸烟、精神压抑、月经不规律及生殖系统手术史是乳腺癌的危险因素 ,经常进食葱类食品和生育是乳腺癌的保护因素
[Objective] To investigate the risk factors of female breast cancer in Guangzhou and provide evidence for the prevention and treatment of breast cancer. [Methods] Using a 1:1 matched case-control study, 348 cases of female breast cancer patients aged from 30 to 74 years old and diagnosed by histopathology from January to June 1997 were investigated by questionnaire. The survey included six aspects of the general situation, living and living environment, eating habits, lifestyle, disease and family history, and women’s physiology and fertility. The relative risk ratio’s approximate estimate odds ratio (OR) was used to estimate the relationship between risk factors and breast cancer. Logistic regression model was used for univariate and multivariate analysis to identify meaningful risk factors. [Results] After multivariate analysis, the variables related to the incidence of breast cancer were the monthly average food intake, lack of physical exercise, passive smoking, mental depression, irregular menstruation and reproductive system surgery history of fish and shrimp ten years ago (P<0.05). The variables that have a protective effect on breast cancer include frequent consumption of onion food and birth (P<0.05). [Conclusion] The average monthly intake of fish and shrimp, lack of physical exercise, passive smoking, mental depression, irregular menstruation, and surgical history of reproductive system 10 years ago are risk factors for breast cancer. Regular consumption of onion foods and fertility are breast cancers. Protective factors