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妊娠期糖尿病(GDM)为糖尿病的一种特殊类型,对母亲和胎儿都有不利影响。GDM孕妇存在比正常孕妇更强烈的胰岛素抵抗,并且胰岛β细胞功能存在缺陷。C反应蛋白、白细胞介素6等炎性因子参与了GDM孕妇慢性炎症的发生。免疫失衡造成细胞毒性因子的释放增加,增加了GDM发生的风险。人类白细胞抗原分子作为免疫调节分子,可能与GDM有一定的关系,GDM孕妇某些人类白细胞抗原基因型频率是增加的。
Gestational diabetes (GDM) is a special type of diabetes that has adverse effects on both mother and fetus. GDM pregnant women have more insulin resistance than normal pregnant women, and pancreatic islet β cell function deficiencies. C-reactive protein, interleukin-6 and other inflammatory cytokines involved in the occurrence of chronic inflammation in GDM pregnant women. Immune imbalance causes increased release of cytotoxic factors, increasing the risk of GDM. Human leukocyte antigen molecules as immunomodulatory molecules may have a certain relationship with GDM, GDM pregnant women, some of the human leukocyte antigen genotype frequency is increased.