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目的通过对新生儿高胆红素血症患儿脑干听觉诱发电位(BAEP)及血清神经元特异性烯醇化酶(NSE)检测,评估高胆红素血症对新生儿听神经损伤。方法 56例血清胆红素大于 220．5μmol／L的新生儿为高胆红素血症组(简称高胆组),血清胆红素小于220．5μmol／L的49例足月儿为对照组,分别进行BAEP、NSE检测。结果高胆组新生儿BAEP的Ⅰ、Ⅲ、Ⅴ波绝对潜伏期(PL)、峰间潜伏期(IPL)均明显延长,与对照组比较,差异有显著性意义(P<0．01);高胆组新生儿NSE明显高于对照组,差异有显著性意义(P<0．01);NSE水平与BAEP的Ⅴ波反应阈值呈正相关(r=0．65,P<0．01)。结论高胆红素血症可导致新生儿听神经损伤;BAEP和NSE对其神经损伤有较高的敏感性,可作为监测指标。
Objective To evaluate the auditory nerve injury of neonates with hyperbilirubinemia through the assessment of brainstem auditory evoked potential (BAEP) and serum neuron specific enolase (NSE) in neonates with hyperbilirubinemia. Methods 56 neonates with serum bilirubin greater than 220.5 μmol / L were hyperbilirubinemia group (49 cases) with full bilirubin less than 220.5 μmol / L as control group , Respectively, BAEP, NSE test. Results The absolute latency (PL) and peak latency (IPL) of BAEP were significantly increased in neonatal group with hyperbilirubinemia compared with the control group (P <0.01) The neonatal NSE was significantly higher than that of the control group (P <0.01). The NSE level was positively correlated with the wave response threshold of BAEP (r = 0.65, P <0.01). Conclusions Hyperbilirubinemia can lead to neonatal auditory nerve injury. BAEP and NSE have higher sensitivity to nerve injury and can be used as monitoring indicators.