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目的 :观察和分析食管癌根治术患者预后的相关研究。方法 :选取180例行根治术的食管鳞癌患者作为研究对象,对其性别、年龄、体质指数、病变部位、肿瘤长度、分化程度、外侵程度、远处转移、术后病理TNM分期、淋巴结转移情况、手术方式、残端受侵、吻合口瘘、术后感染等情况进行记录和比较。对患者进行术后随访,对其总生存期(OS)进行分析和比较。结果 :具有不同的病变部位、肿瘤长度、分化程度、外侵程度、TNM分期、淋巴结转移、术后感染的患者的OS中位数估计值的差异均有统计学意义,Cox多元回归分析结果显示,食管癌根治术患者的预后与肿瘤的分化程度(RR=0.582)、侵润程度(RR=1.453)、肿瘤长度(RR=1.337)、淋巴结转移(RR=2.257)及患者术后感染(RR=1.637)具有相关性。结论 :食管癌根治术患者的预后与多种因素具有相关性,临床医生应准确识别高危因素并采用及时有效的干预措施,从而达到改善患者预后的目标。
Objective: To observe and analyze the prognosis of esophageal cancer patients undergoing radical resection. Methods: 180 cases of esophageal squamous cell carcinoma undergoing radical resection were selected as the research object. Their gender, age, body mass index, lesion location, tumor length, differentiation degree, extent of invasion, distant metastasis, postoperative pathological TNM stage, lymph node Metastasis, surgical methods, stump invasion, anastomotic fistula, postoperative infection and other conditions were recorded and compared. The patients were followed up and their overall survival (OS) was analyzed and compared. Results: There were significant differences in OS median estimates among patients with different lesion sites, tumor length, differentiation degree, degree of invasion, TNM stage, lymph node metastasis and postoperative infection. Cox multivariate regression analysis showed that there was significant difference (RR = 0.582), degree of invasion (RR = 1.453), tumor length (RR = 1.337), lymph node metastasis (RR = 2.257) and postoperative infection = 1.637). Conclusion: The prognosis of esophageal cancer patients with radical mastectomy is correlated with many factors. Clinicians should accurately identify the risk factors and adopt timely and effective interventions to achieve the goal of improving the prognosis of patients.