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目的 探讨C erbB -2癌基因在Hp感染中的表达与胃癌、胃炎及正常组织的关系。方法 采用免疫组化卵白素 生物素 辣根过氧化酶法 ,分别检测正常组织 2 1例 ,浅表性胃炎 2 2例 ,胃癌 2 7例C erbB -2癌基因抗体的表达变化。结果 C erbB -2在 70例Hp感染者中随胃粘膜病理变化不同而增高 ,其中 ,正常组织的阳性率为 19% (4/ 2 1) ,浅表性胃炎为 77 2 7% (17/ 2 2 ) ,胃腺癌为 10 0 % (2 7/ 2 7) ,相互之间均有显著性差异 (P <0 0 1) ;同时 ,随着组织类型变化 ,炎症出现 ,免疫反应类型由镶嵌型向局灶型和弥漫型转变。结论 C erbB -2癌基因的异常表达对胃炎、胃癌的形成有一定作用 ,与胃腺癌的发生有密切关系
Objective To investigate the relationship between the expression of C erbB-2 oncogene and Hp infection in gastric cancer, gastritis and normal tissues. Methods Immunohistochemical avidin biotin horseradish peroxidase method was used to detect the changes of the expression of C erbB -2 oncogene antibodies in 21 cases of normal tissues, 22 cases of superficial gastritis and 27 cases of gastric cancer. Results The positive rate of C erbB -2 increased with the pathological changes of gastric mucosa in 70 Hp infected patients. The positive rate of C erbB -2 was 19% (4/21) in normal tissues and 77 2 7% (17 / 2 2), and gastric adenocarcinoma was 100% (27/27) (P <0.01). At the same time, with the change of tissue type and inflammation, the type of immune reaction was changed from mosaic Type to the focal and diffuse changes. Conclusion Aberrant expression of C erbB-2 oncogene plays a role in the formation of gastritis and gastric cancer, which is closely related to the occurrence of gastric adenocarcinoma