此项研究目的是比较单用大剂量α-干扰素(疗程12月)与利巴韦林、α-干扰素联合治疗1b基因型慢性丙型肝炎的疗效。 研究对象包括307例治疗前ALT水平升高、血清HCV RNA阳性且活检证实慢性肝炎的1b基因型慢性丙型肝炎病人,随机分为三组,A组95人.给予α2b-干扰素,6Mu,皮下注射,每周3次,6月后改为3Mu,每周3次,再用6月;B组83人,给予α2b-干扰素,10Mu及6Mu,皮下注射,每周3次,各3月后改为3Mu, The aim of this study was to compare the efficacy of high-dose α-interferon alone (in December) with ribavirin and interferon-α in the treatment of genotype 1b chronic hepatitis C. A total of 307 patients with genotype 1b genotype 1b chronic hepatitis C who had elevated serum ALT levels, positive serum HCV RNA and biopsy-proven chronic hepatitis B were randomly divided into three groups: group A, 95. Patients given α2b-interferon, 6Mu, Subcutaneous injection, 3 times a week, 6 months later changed to 3Mu, 3 times a week, and then in June; B group of 83 people, given α2b-interferon, 10Mu and 6Mu, subcutaneous injection 3 times a week, 3 After the change to 3Mu,