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[目的]探讨肾结石患者尿液中三叶因子1(TFF1)、单核细胞趋化蛋白‐1(MCP‐1)表达水平及意义.[方法]选取2017年1月至2018年4月本院收治的103例肾结石患者(观察组) ,选择同期于本院健康体检志愿者100例作为对照组,检测两组血钙、肌酐等血清生化指标,检测尿液 TFF1 、MCP‐1及尿钙水平.[结果]观察组与对照组血钙、肌酐、尿酸及尿素氮水平比较,差异无统计学意义( P ＞0 .05).观察组尿液T FF1水平明显低于对照组,而MCP‐1 、尿钙明显高于对照组,差异均有统计学意义( P ＜0 .05) .观察组肾小球滤过率估算值(eGFR)为(88 .10 ± 32 .20)[mL／(min·1 .73 m2 )] ,将观察组患者尿液 T FF1 、MCP‐1 、尿钙与eGFR进行相关分析,结果显示,尿液TFF1与尿钙呈显著负相关( r ＝ －0 .433 ,P ＜0 .05) ;尿液MCP‐1与尿钙呈正相关( r ＝0 .404 ,P ＜0 .05) ,与eGFR呈负相关( r ＝ －0 .362 ,P ＜0 .05) .[结论]肾结石患者尿液TFF1水平降低,而MCP‐1水平增高,两者与患者尿钙及eGFR有一定的相关性.“,”To investigate the levels and significance of trilobal factor 1 (T FF1) and monocyte chemoattractant protein 1 (MCP 1) in urine of patients with renal calculi .[M ethods]From January 2017 to A‐pril 2018 ,103 patients with renal calculi were selected as observation group and 100 healthy volunteers as con‐trol group ,serum biochemical parameters such as serum calcium and creatinine in two groups were detected , urine T FF1 ,MCP‐1 and urinary calcium level were detected .[Results]T here was no significant difference in serum calcium ,creatinine ,uric acid and urea nitrogen between the observation group and the control group ( P ＞0 .05).T he levels of T FF1 in urine of the observation group were significantly lower than those of the control group ,w hile the levels of MCP‐1 and urinary calcium were significantly higher than those of the con‐trol group ( P ＜0 .05).The estimated glomerular filtration rate (eGFR) of the observation group was (88 .10 ± 32 .20)[mL／(min·1 .73 m2 )].T he correlation analysis of urine T FF1 ,MCP‐1 ,urine calcium and eGFR in the observation group showed that urine T FF1 was negatively correlated with urine calcium ( r ＝ －0.433 , P＜0 .05) ,urine MCP‐1 was positively correlated with urine calcium ( r ＝ 0 .404 , P ＜0 .05) ,and negatively correlated with eGFR ( r ＝ －0 .362 ,P ＜0 .05).[Conclusion]T he level of T FF1 in urine of patients with renal calculi decreases ,w hile the level of MCP‐1 increases ,w hich is correlated with urinary calcium and eGFR in patients with renal calculi .