论文部分内容阅读
目的:探讨血清及尿中Kim-1及CysC联合监测在临床诊断急性肾衰竭中的意义及价值。方法:选取我院重症监护病房的泌尿系统疾病患者108例根据急性肾衰竭诊断标准将其分为两组:58例符合急性肾衰竭诊断标准为ARF组,50例非急性肾衰竭为非ARF组,另取正常体检的健康人5 0例为正常对照组,检测三组患者的血清肌酐浓度、血清尿素氮、血清和尿KIM-1及Cys-C浓度,进而对血清和尿KIM-1及Cys-C水平进行分析。结果:与对照组和非ARF组相比,ARF组血清肌酐浓度、血清尿素氮、血清和尿KIM-1及Cys-C水平较高(P<0.05)。与血清和尿KIM-1及Cys-C水平的单独检测相比,两者联合检测敏感性以及特异性较高(P<0.05)。结论:血清及尿中Kim-1及CysC水平升高可作为急性肾衰竭的评估指标,两者联合监测对急性肾衰竭患者的诊断具有重要意义,对疾病预后有重要指导价值。
Objective: To investigate the significance and value of combined monitoring of serum and urinary Kim-1 and CysC in clinical diagnosis of acute renal failure. Methods: A total of 108 patients with urinary system diseases from our intensive care unit were divided into two groups based on the diagnostic criteria of acute renal failure: 58 patients with acute renal failure (ARF), 50 patients with non-acute renal failure , And another 50 normal healthy subjects were taken as normal control group. Serum creatinine concentration, serum urea nitrogen, serum and urinary KIM-1 and Cys-C concentrations were measured in three groups of patients, and then serum and urinary KIM-1 and Cys-C levels were analyzed. Results: Serum creatinine, serum urea nitrogen, serum and urinary KIM-1 and Cys-C were significantly higher in ARF group than those in control group and non-ARF group (P <0.05). Compared with the separate detection of KIM-1 and Cys-C in serum and urine, the sensitivity and specificity of combined detection of the two were higher (P <0.05). Conclusion: The elevated serum levels of Kim-1 and CysC can be used as an index for the assessment of acute renal failure. The combined monitoring of them is of great significance in the diagnosis of patients with acute renal failure, and has an important guiding value for the prognosis of the disease.