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目的：研究肝脏血流控制优化方法的动物模型建立与其机制。方法建立3种不同阻断方式肝脏缺再灌注损伤模型，观察再灌注24 h 及7 d 实验动物存活率、肝断面出血量、肝组织内血流灌注压变化，结合病理学常规方法，筛选出一种优化的肝门血流控制方式。结果再灌注24 h 存活率：Pringle 法组46．7％、半肝血流阻断组93．3％、尾状叶分流保留动脉阻断门静脉组100％；半肝血流阻断组与尾状叶分流保留动脉阻断门静脉组肝细胞受损率较 Pringle 法组明显降低；Pringle 法组阻断后肝内灌注压会突然上升至正常水平的3．4倍；3种阻断肝门血流控制法阻断肝脏血流后，肝断面仍然有一定的出血量。结论尾状叶分流保留动脉阻断门静脉血供方法，能明显降低由于肝门阻断引起的肝脏缺血再灌注损伤，是一种安全有效的肝门血流控制方法。“,”Objective To survey the establishments of animal models of control optimization of liver blood flow and mechanisms .Methods An optimal porta hepatis blood flow control mode was screened from 3 liver ischemia‐reperfusion injury models of different occlusion modes in combination with pathological rou‐tine methods via observing survival rate of laboratory animals in the 24th hour and 7th day after reperfusion , blood loss in hepatic cross section and perfusion pressure changes of hepatic tissue blood flow .Results Survival rate in the 24th hour after reperfusion was 46 .7% in Pringle’s maneuver group ,93 .3% in half liver blood supply occlusion and 100% in caudate lobe shunt maintaining artery blocking the portal vein ;hepa‐tocyte damage rates lowered significantly in latter 2 groups than in the former ;hepatic perfusion pressure suddenly went up to 3 .4 times the normal level in Pringle’s maneuver group ;liver section still had a cer‐tain amount of blood loss after blocking liver blood flow with 3 methods .Conclusion Caudate lobe shunt maintaining artery blocking the portal vein could notably lower liver ischemia‐reperfusion injury due to he‐patic portal occlusion and is a safe and effective method controlling hepatic portal blood flow .