论文部分内容阅读
目的观察p53蛋白和survivin蛋白表达对直肠癌分级和预后影响分析。方法采用免疫组化法检测60例直肠癌组织和30例正常直肠组织中p53蛋白和survivin蛋白表达水平,并比较其表达水平和直肠癌分级和预后之间的关系。结果直肠癌组织中p53蛋白和survivin蛋白表达率均显著上升。低分化的癌组织中survivin表达水平显著高于高分化组织(P<0.05)。T_1~T_2分级和长生存期的癌组织中p53表达水平显著低于T_3~T_4分级和短生存期的癌组织(P<0.05);survivin和p53表达水平无相关性(P>0.05)。结论 p53蛋白和survivin蛋白高表达可作为直肠癌发生及预后的判别指标之一。
Objective To investigate the effect of p53 protein and survivin protein expression on the classification and prognosis of rectal cancer. Methods Immunohistochemistry was used to detect the expression of p53 protein and survivin protein in 60 cases of rectal cancer and 30 cases of normal rectal tissue. The relationship between the expression of p53 protein and survivin protein was compared with the classification and prognosis of rectal cancer. Results The expression of p53 protein and survivin protein in rectal cancer tissues were significantly increased. The expression of survivin in poorly differentiated carcinoma tissues was significantly higher than that in well differentiated tissues (P <0.05). The expression of p53 in T 1 ~ T 2 grade and long-term cancer tissues was significantly lower than that in T 3 ~ T 4 grade and short-term cancer tissues (P <0.05). There was no correlation between the expression of survivin and p53 (P> 0.05). Conclusion The high expression of p53 protein and survivin protein may be one of the distinguishing criteria for the occurrence and prognosis of rectal cancer.