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目的:探讨老年患者地高辛中毒症状的临床特点。方法:收集诊断为地高辛中毒的老年患者80例,对其临床资料进行回顾性分析研究。结果:80例患者中CDGX为(3.40±1.05)ng/mL,血Cr(187.5±110)μmol/L,133μmol/L 27人;BUN(16.5±9.2)mmol/L,大于7.1mmol/L者20人;血清钾(4.3±0.95)mmol/L,大于5.5mmol/L者15例;合并应用已知并能使CDGX升高药物者18人,其中1种12例,2种3例,3种以及3种以上3例。在出现地高辛中毒症状的患者中,胃肠道反应46例,头痛16例,视力模糊18例;心电图检查:室性早搏32例,房颤35例,交界性逸搏心律13例。结论:地高辛中毒的原因和表现有很多种,表现为多因素性,因此在使用地高辛时,应对患者的生理、心理和病理等方面进行详细的了解和分析。尤其是老年地高辛中毒患者,其临床症状表现不典型,跟肝、肾功能不全以及合并用药等多种因素息息相关。因此,应及时调整用药浓度,分析并制定最佳用药方案。
Objective: To investigate the clinical features of digoxin poisoning in elderly patients. Methods: Eighty elderly patients diagnosed with digoxin poisoning were collected and their clinical data were retrospectively analyzed. Results: The CDGX in 80 patients was (3.40 ± 1.05) ng / mL, blood Cr (187.5 ± 110) μmol / L and 133μmol / L were 27 and BUN was 16.5 ± 9.2 mmol / L, 20; serum potassium (4.3 ± 0.95) mmol / L, more than 5.5mmol / L in 15 cases; combined with known and can make CDGX drug increased in 18 people, including 1 in 12 cases, 2 in 3 cases, 3 And three kinds of more than 3 cases. In patients with symptoms of digoxin poisoning, 46 cases of gastrointestinal reactions, headache in 16 cases, blurred vision in 18 cases; ECG: ventricular premature beats in 32 cases, atrial fibrillation in 35 cases, 13 cases of borderline escape rhythm. Conclusion: There are many causes and manifestations of digoxin poisoning and its manifestations are multifactorial. Therefore, when digoxin is used, we should make a detailed understanding and analysis of the patients’ physiology, psychology and pathology. Especially elderly patients with digoxin poisoning, the clinical manifestations of atypical, with the liver, renal insufficiency and combination of medication and other factors are closely related. Therefore, we should promptly adjust the drug concentration, analysis and development of the best drug program.