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目的：探讨孤立性浆细胞瘤和多发性骨髓瘤间的关系。方法：对27例孤立性浆细胞瘤进行临床分析。结果：提示孤立性浆细胞瘤中的74．07％的患者衍变为多发性骨髓瘤，其衍变的时间长短不一；其衍变和瘤细胞的病理类型明显相关，术后常规的化疗及放疗和其衍变无统计学相关意义。结论：孤立性浆细胞瘤多数将衍变为多发性骨髓瘤，在诊断孤立性浆细胞瘤成立后应将其视为一种单独的疾病，采取恰当的治疗手段能阻止或延后其衍变。
Objective: To investigate the relationship between solitary plasmacytoma and multiple myeloma. Methods: 27 cases of solitary plasmacytoma were analyzed clinically. RESULTS: It was suggested that 74.07% of patients with solitary plasmacytoma developed multiple myeloma, and the duration of their development varied; their evolution was associated with the pathological type of the tumor cells, and conventional chemotherapy and radiotherapy were performed after surgery. Its evolution was not statistically significant. CONCLUSIONS: Most solitary plasmacytomas will be transformed into multiple myeloma, which should be considered as a single disease after the diagnosis of solitary plasmacytoma is established. Proper treatment can prevent or delay its evolution.