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研究表明,血小板衍生生长因子(PDGF)在PTA后RS的形成过程中发挥重要的介导作用。PDGF两种亚单位(A链及B链),可形成同二聚体和异二聚体,结合并激活两个同源的酪氨酸-激酶受体(PDGF-α受体和PDGF-β受体)[1]。损伤的血管内皮细胞(VEC)、激活的血小板、移行于内皮下的单核巨噬细胞
Studies have shown that platelet-derived growth factor (PDGF) plays an important role in the formation of RS after PTA. PDGF two subunits (A and B chains), can form homodimers and heterodimers, bind and activate two homologous tyrosine-kinase receptors (PDGF-α receptor and PDGF-β Receptor) [1]. Damaged Vascular Endothelial Cells (VEC), Activated Platelets, Mononuclear Macrophages Transmigrating Under Endothelium