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目的探讨环孢素A(cyclosporine A,CsA)联合氟康唑治疗真菌性角膜炎的临床效果。方法将127例真菌性角膜炎患者随机分为两组,A组为常规组采取氟康唑药物治疗,B组为治疗组在A组氟康唑治疗基础上加用CsA治疗。结果 B组在视力恢复、显效率及总有效率上明显优于A组,无效率也明显低于A组,差异有统计学意义。结论 CsA联合氟康唑能明显提高真菌性角膜炎的治疗效果,可作为一线局部抗真菌药物使用。
Objective To investigate the clinical effect of cyclosporine A (CsA) combined with fluconazole in the treatment of fungal keratitis. Methods A total of 127 patients with fungal keratitis were randomly divided into two groups. Group A was treated with fluconazole in the conventional group, while group B was treated with CsA in group A with fluconazole. Results Group B was significantly better than group A in visual recovery, effective rate and total effective rate, and the inefficiency rate was significantly lower in group B than in group A, the difference was statistically significant. Conclusion CsA combined with fluconazole can significantly improve the therapeutic effect of fungal keratitis, which can be used as topical antifungal agents.