论文部分内容阅读
目的:探讨鱼油脂肪乳对严重创伤病人血清炎性递质水平调节作用和预后的影响。方法:选择严重创伤病人(ISS评分>16分)40例,随机分为两组,A组为对照组,B组加用鱼油脂肪乳0.2 g/(kg·d)。两组病人均接受等氮、等热量的全胃肠外营养(TPN),并于治疗前和治疗后第3、5和7天分别检测两组病人的血清C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-1(IL-1)和IL-6的水平。统计两组病人多器官功能障碍综合征(MODS)的发生率和28 d病死率。结果:B组病人治疗后不同时间点血清CRP、TNF-α、IL-1和IL-6均明显降低,与A组比差异有显著性统计学意义(P<0.05)。B组MODS发生率明显下降(P<0.05),28 d病死率有所降低,但无显著性差异。结论:鱼油脂肪乳可调节严重创伤病人炎性递质的释放,降低严重创伤病人血清CRP、TNF-α、IL-1和IL-6水平,能减少严重创伤病人MODS的发生率。
Objective: To investigate the effects of fish oil fat emulsion on the level of inflammatory mediators and the prognosis of severe traumatic patients. Methods: Forty patients with severe traumatic injury (ISS score> 16) were randomly divided into two groups, group A was control group, group B was supplemented with 0.2 g / (kg • d) of fish oil fat emulsion. Both groups received equal total parenteral nutrition (TPN) such as nitrogen and calorie. Serum C-reactive protein (CRP) and tumor necrosis were measured in both groups before treatment and on days 3, 5 and 7 after treatment Factor alpha (TNF-alpha), interleukin-1 (IL-1) and IL-6 levels. The incidence of multiple organ dysfunction syndrome (MODS) and 28-day mortality in both groups were calculated. Results: The serum levels of CRP, TNF-α, IL-1 and IL-6 in group B were significantly lower than those in group A at different time points after treatment (P <0.05). The incidence of MODS in group B was significantly decreased (P <0.05), and the mortality was reduced at 28 days, but no significant difference was found. Conclusion: Fish oil emulsion can regulate the release of inflammatory neurotransmitters in severe traumatic patients and reduce the levels of serum CRP, TNF-α, IL-1 and IL-6 in severe traumatic patients and reduce the incidence of MODS in severe traumatic patients.