三尖杉酯碱(Harringtonine)已广用于临床,对白血病尤其是急性粒细胞白血病有较好疗效。三尖杉酯类生物碱和三尖杉酯碱与高三尖杉酯碱混合物在静脉滴注时,可出现心动过速及暂时性心电图改变[1、2]。动物亚急性毒性实验证明,三尖杉酯碱的毒性作用主要表现在胃肠道、心脏和造血器官,大多数中毒致死的原因皆归因于心功能障碍[3]。为了探讨三尖杉酯碱对心血管的作用特点,本文观察了该药对不同动物血压和心电图的影响。 Harringtonine has been widely used clinically and has a good effect on leukemia, especially acute myeloid leukemia. Tricaprin alkaloids and harringtonine and homoharringtonine mixture in the intravenous infusion, there may be tachycardia and temporary ECG changes [1,2]. Animal subacute toxicity experiments show that the toxic effect of harringtonine mainly in the gastrointestinal tract, heart and hematopoietic organs, most of the causes of poisoning are due to cardiac dysfunction [3]. In order to investigate the effect of harringtonine on cardiovascular function, we observed the effect of this drug on blood pressure and electrocardiogram in different animals.