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目的 :探讨药物对高原人体运动时一氧化氮 (NO)及其NO合酶 (NOS)的影响 ;方法 :对进驻海拔 41 0 0m高原 2 0天的 5 0名健康青年随机分为吸入NO组、红景天组、乙酰唑胺组、西氏胶囊组和对照组 ,每组 1 0人 ,在安静时、服 (吸入 )药前后及踏阶运动后分别检测血中NO、NOS含量 ;结果 :5组青年安静时、服 (吸入 )药前、踏阶运动后NO和NOS均无显著性差异 (P >0 .0 5 ) ;运动后较安静时NO、NOS均增高 ,有显著性差异 (P <0 .0 5或P <0 .0 1 ) ;服药后较服药前 ,红景天组、吸入NO组NO和NOS均增高 ,有显著性意义 (P <0 .0 5或P <0 .0 1 ) ;乙酰唑胺组、西氏胶囊组NOS增高 ,有显著性意义 (P <0 .0 5 ) ,NO无统计学意义 (P >0 .0 5 ) ;与对照组比较 ,NOS均增高显著 (P <0 .0 5或P <0 .0 1 ) ,NO在吸入NO组和红景天组增高显著 (P <0 .0 5 ) ,乙酰唑胺组、西氏胶囊组NO、NOS均降低显著 (P <0 .0 5或P <0 .0 1 ) ,红景天组无统计学意义 (P >0 .0 5 ) ;与红景天组比较 ,乙酰唑胺组、西氏胶囊组NOS降低非常显著 (P<0 .0 1 ) ,NO无统计学意义 (P >0 .0 5 ) ;乙酰唑胺组与西氏胶囊组比较 ,NO、NOS均无统计学差异 (P >0 .0 5 ) ;结论 :4种药物均不同程度增强高原运动时NOS活性 ,增加血中NO含量 ,但吸入NO和服用红景天效果更?
Objective: To investigate the effects of drugs on nitric oxide (NO) and nitric oxide synthase (NOS) during altitude movement in human body. Methods: Fifty healthy youths stationed at 4100 m above sea level at 20 days were randomly divided into inhaled NO group , Rhodiola group, acetazolamide group, Cis capsule and control group, with 10 in each group. NO and NOS in blood were measured before and after serving (inhalation) and treadmill exercise respectively. Results : There was no significant difference in NO and NOS between treadmill exercise and before exercise (inhalation) in 5 groups of young people (P> 0.05), NO and NOS increased after exercise (P <0.05 or P <0.01). Before treatment, the levels of NO and NOS in the Rhodiola rosea group and inhaled NO group were significantly increased (P <0.05 or P < (P <0.05). There was no significant difference between the two groups (P> 0.05). Compared with the control group, the NOS in acetazolamide group and Xishi capsule group were significantly increased NOS increased significantly (P <0.05 or P <0.01), NO increased significantly (P <0. 05) in inhaled NO and Rhodiola rosea group, NO and NOS decreased significantly (P <0.05 or P <0.01), Rhodiola no statistics (P> 0.05) .Compared with Rhodiola rosea group, the decrease of NOS in acetazolamide group and Xishi capsule group was significant (P <0.01), and NO was not statistically significant (P> 0.05) 5). There was no significant difference between NO and NOS in the acetazolamide group and the Cis capsule group (P> 0.05). CONCLUSION: The four drugs all enhanced the activity of NOS in plateau at different degrees and increased NO Content, but inhaled NO and Rhodiola more effective?