脑源性神经营养因子(brain derived neurotrophic factor, BDNF)参与体内多种病理生理过程,调节细胞生长分化,在神经损伤修复中起重要作用。BDNF与中枢神经系统疾病关系密切,它对神经系统的损伤有较好的保护作用。但它的作用机制及高压氧作用下的变化情况还不太清楚。本实验复制了小鼠全脑性缺血再灌注模型,观察高压氧对缺血再灌注损伤脑组织的病理形态及BDNF表达的影响。 Brain derived neurotrophic factor (BDNF) is involved in various pathophysiological processes and regulates cell growth and differentiation, and plays an important role in the repair of nerve injury. BDNF and the central nervous system diseases are closely related, it has a good protective effect of the nervous system damage. But its mechanism of action and changes under the action of hyperbaric oxygen is not yet clear. In this study, a mouse model of global cerebral ischemia-reperfusion was reproduced and the effect of hyperbaric oxygen on the pathological changes of cerebral ischemia-reperfusion and the expression of BDNF were observed.