本文总结应用第二代DNA重组hGH(Genotro Pin,Sweden)连续2年治疗20例青春发育前典型严重特发性生长激素缺乏症的结果。其中男15例,女5例,治疗前均经L-Dopa和Clonidine激发试验确诊为GH缺乏,治疗剂最为0.1IU/kg·日,每天1次皮下注射,每3～6个月随访1次。治疗第一年身高增加12.0±2.1cm,治疗第二年身高增加8.2±2.2cm,效果满意。还证实治疗时的年龄、骨龄与第一年和3年的增长速率呈负相关。 This article summarizes the results of the treatment of 20 cases of pre-puberty typical severe idiopathic growth hormone deficiency by Genotro Pin (Sweden) for 2 consecutive years. There were 15 males and 5 females, all of whom were diagnosed with GH deficiency by L-Dopa and Clonidine challenge test before treatment. The most therapeutic agent was 0.1 IU / kg · day, once a day for subcutaneous injection every 3 to 6 months . The height of the first year of treatment increased 12.0 ± 2.1cm, the height of the second year of treatment increased 8.2 ± 2.2cm, with satisfactory results. Also confirmed that the treatment of age, bone age and the first year and 3 years of growth rate was negatively correlated.