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非酒精性脂肪性肝病(NAFLD)涵盖了一系列脂肪毒性疾病,包括单纯性脂肪肝至具有纤维化倾向的非酒性脂肪性肝炎(NASH)等。虽然NASH可继发于其他病因(如药物等),但大多数患者由代谢因素所致。NASH的诊断基于临床和病理学标准。前者包括证实胰岛素抵抗(IR)的存在,并排除其他肝脏疾病。NASH的肝病理组织学变化包括脂肪变性、坏死、小叶炎症及不同程度的纤维化。在发达国家中,NAFLD是肝功能异常最为常见的原因,其流行率为10%～20%。NASH可进展为肝硬化,在这种情况下其预后与HCV感染性肝硬化患者相似。
Non-alcoholic fatty liver disease (NAFLD) covers a range of fatty toxic diseases, ranging from simple fatty liver to fibrosis-prone non-alcoholic steatohepatitis (NASH). Although NASH can be secondary to other causes (such as drugs, etc.), most patients are caused by metabolic factors. The diagnosis of NASH is based on clinical and pathological criteria. The former includes confirmation of the presence of insulin resistance (IR) and exclusion of other liver diseases. Histopathological changes in liver cirrhosis include steatosis, necrosis, lobular inflammation and varying degrees of fibrosis. In developed countries, NAFLD is the most common cause of liver dysfunction, the prevalence of 10% to 20%. NASH progresses to cirrhosis, in which case its prognosis is similar to that in patients with HCV-infected cirrhosis.