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邻苯二甲酸酯(phthalate acid esters,PAEs)是一类常用的增塑剂,广泛地存在于人们日常生活环境中,如塑料制品、化妆品、食品包装、儿童玩具等。PAEs对机体存在毒性作用,不仅可影响生物体的内分泌系统,也可对生物体的心、肝、肺、肾及生殖等系统产生慢性毒性作用。本文就PAEs对胚胎发育不同阶段的毒性影响及其可能机制进行综述。
Phthalate acid esters (PAEs) are a kind of commonly used plasticizers, widely exist in people’s daily life environment, such as plastic products, cosmetics, food packaging, children’s toys and so on. PAEs on the body of toxic effects, not only can affect the organism’s endocrine system, but also on the organism’s heart, liver, lung, kidney and reproductive systems have a chronic toxicity. This article reviews the effects of PAEs on the toxicity of different stages of embryonic development and its possible mechanism.