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髓鞘厚度取决于轴突纤维的体积,髓鞘形成需要轴突信号传导。该文作者应用突变型和转基因鼠系揭示轴突神经调节素-1(Nrg1)向雪旺细胞传导关于轴突体积的信号,证实NrglⅢ是起作用的异构体,轴突配体Nrg和胶质受体ErbB结合细胞表面信号而相互作用。成熟鼠坐骨神经表达Nrg1、ErbB2和ErbB3。ErbB2与髓鞘化相关,存在于雪旺细胞。轴突固有直径和髓鞘纤维外径间的数量比值为纤维g值。基因打靶复制杂合体鼠。2日、10日和6月龄杂合体鼠坐骨神经的Nrg1和胶质ErbB2量降至野生型鼠的一半.10
Myelin thickness depends on the volume of axonal fibers, and myelination requires axon signaling. Using the mutant and transgenic murine lines, the authors revealed that axon neurotensin-1 (Nrg1) transduces signals on axonal volume to Schwann cells confirming that NrglIII is a functional isoform, axonal ligand Nrg and glue The receptor, ErbB, interacts with cell surface signaling. Mice sciatic nerve express Nrg1, ErbB2 and ErbB3 in mature mice. ErbB2 is associated with myelination and is present in Schwann cells. Axonal intrinsic diameter and the number of myelin fiber diameter ratio between the value of fiber g. Gene targeting replication hybrid mice. The amounts of Nrg1 and glial ErbB2 in the sciatic nerve of hybrid mice at 2, 10 and 6 months were reduced to half of that in wild-type mice.10