作者报告一例原发性皮肤球孢子菌病。患者女性,31岁。发病前曾用粗球孢子菌悬液作小鼠接种。患者回忆接种前和接种过程中无外伤史。于接种后一月余发现左手食指有一高起皮损,一周后皮损增大。但患者不发烧,无不适,也无呼吸道症状。患者发病前4个月曾作球孢子菌素试验阴性。检查发现: The authors report a case of primary cutaneous coccidioidomycosis. Patient female, 31 years old. Before the onset of Coccidioidomycosis suspension for mice inoculated. Patients recalled the history of vaccination before vaccination and no history of trauma. More than a month after inoculation found that the left index finger has a high skin lesions, skin lesions increased after a week. However, patients with no fever, no discomfort, no respiratory symptoms. The patient had a negative cocetin test 4 months before onset. Examination revealed: