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目的:观察加味附子理中汤减轻中晚期直肠癌化疗后引起的骨髓抑制的临床疗效。方法:将78例直肠癌需要化疗的患者随机分为试验组和对照组各39例,对照组为单纯化疗组,试验组为化疗结合加味附子理中汤组,2组治疗过程中观察患者骨髓抑制的发生情况。结果:化疗前第1天,2组白细胞计数及中性粒细胞百分比比较,差异均无统计学意义(P>0.05)。化疗后第10天,2组白细胞计数、中性粒细胞百分比均有不同程度降低,但对照组降低幅度更明显,2组白细胞计数及中性粒细胞百分比比较,差异有统计学意义(P<0.05)。对照组有1例患者因出现药物过敏反应退出本研究。结论:加味附子理中汤在化疗前后口服能够减轻中晚期直肠癌患者化疗后的引起的骨髓抑制,值得在临床上进一步推广。
Objective: To observe the therapeutic effect of Jiawei Fuzi Lizhong Tang on myelosuppression induced by chemotherapy of advanced rectal cancer. Methods: 78 patients with rectal cancer who needed chemotherapy were randomly divided into experimental group and control group, 39 cases in each group. The control group was chemotherapy alone. The experimental group was treated with chemotherapy plus flavored Fuzi Li Zhong Tang. The bone marrow Suppression of the situation. Results: On the first day before chemotherapy, there was no significant difference in the white blood cell count and neutrophil percentage between the two groups (P> 0.05). On the 10th day after chemotherapy, the white blood cell count and the percentage of neutrophils in both groups decreased to some extent, but the reduction rate in the control group was more obvious. There was significant difference between the two groups in white blood cell count and neutrophil percentage (P < 0.05). One patient in the control group dropped out of the study because of an allergic reaction to the drug. Conclusions: Jiafufuzizhong Decoction orally before and after chemotherapy can alleviate the bone marrow suppression induced by chemotherapy in patients with advanced and advanced rectal cancer, which is worth further promotion in clinic.