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目的:探讨适形调强放疗联合多西他赛与顺铂化疗(TP方案)治疗晚期食管癌的临床疗效及不良反应。方法:将68例晚期食管癌患者随机分为两组,即单纯接受调强放疗治疗的放疗组和接受联合调强放疗及TP化疗的联合组,每组34例。对比两组临床治疗效果。结果:联合组治疗有效率为76.64%,优于放疗组的44.11%,差异有统计学意义(P<0.05);两组治疗放射性肺炎、乏力并发症发生率比较差异无统计学意义(P>0.05)。两组恶心呕吐、骨髓抑制并发症发生率比较差异有统计学意义(P<0.05)。联合组随访3年的死亡率及肿瘤转移率分别为64.70%及14.71%,明显低于放疗组的88.23%及35.29%(均P<0.05)。结论:对晚期食管癌患者行调强放疗联合TP方案化疗可有效地提高临床治疗效果和改善患者的预后。
Objective: To investigate the clinical efficacy and side effects of conformal intensity modulated radiation therapy combined with docetaxel and cisplatin chemotherapy (TP regimen) in the treatment of advanced esophageal cancer. Methods: Sixty - eight patients with advanced esophageal cancer were randomly divided into two groups: radiotherapy group receiving simple intensity modulated radiotherapy and combined therapy receiving combined intensity modulated radiotherapy and TP chemotherapy, with 34 cases in each group. Comparison of two groups of clinical treatment. Results: The effective rate of combined therapy was 76.64%, which was better than that of radiotherapy group (44.11%) (P <0.05). There was no significant difference between the two groups in the treatment of radiation pneumonitis (P> 0.05). Nausea and vomiting in both groups, the incidence of complications of bone marrow suppression was statistically significant difference (P <0.05). The 3-year follow-up mortality and tumor metastasis rates were 64.70% and 14.71% in the combined group, which were significantly lower than 88.23% and 35.29% in the radiotherapy group (all P <0.05). Conclusion: The treatment of advanced esophageal cancer patients with intensity modulated radiotherapy and TP chemotherapy can effectively improve the clinical effect and improve the prognosis of patients.