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采用放射配体结合实验，研究大鼠对烟碱形成依赖后脑皮层Ｍ、Ｎ胆碱能受体的变化，结果显示，形成烟碱依赖后脑皮层Ｍ－受体的亲和力与密度均无改变；Ｎ－受体亲和力也无明显变化，而Ｎ－受体密度则从对照组的９０ｆｍｏｌ·ｍｇ－１±ｓ５ｆｍｏｌ·ｍｇ－１蛋白上调到１３１ｆｍｏｌ·ｍｇ－１±ｓ９ｆｍｏｌ·ｍｇ－１蛋白。表明烟碱依赖与脑Ｎ－受体上调相关。
Radioligand binding assay was used to study the changes of M, N cholinergic receptors in cerebral cortex after nicotine dependence. The results showed that there was no change in the affinity and density of M-receptors in cerebral cortex after nicotine dependence. N - receptor affinity did not change significantly, while the N-receptor density from the control group 90fmol · mg-1 ± s5fmol · mg-1 protein up to 131fmol · mg-1 ± s9fmol · mg-1 protein. Nicotine dependence is associated with increased N -receptor uptake.