近半个世纪来,随着化疗药物的不断问世,化学疗法在恶性肿瘤综合治疗中的地位愈来愈重要。特别是儿童白血病化疗的合理应用,使肿瘤治疗的疗效有较大幅度的提高。然而目前临床所应用的化疗药物均缺乏特异性,即在杀伤肿瘤细胞的同时亦会不同程度地损害机体的正常组织细胞,产生许多 Nearly half a century, with the continuous advent of chemotherapy drugs, chemotherapy in the treatment of malignant tumors more and more important position. In particular, the rational application of chemotherapy for childhood leukemia, so that the efficacy of cancer treatment has a more substantial increase. However, the current clinical application of chemotherapy drugs are lack of specificity, that is, while killing tumor cells will also damage the body to varying degrees, the normal tissue cells, resulting in many