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目的探讨与肝脏损害有关的细胞因子IL-8、IL-12和TNF-α的变化在不同时期的肝硬化及不同肝功能状况的关系,以期阐明细胞因子检测在肝硬化失代偿发生临床意义和部分机制。方法研究选用肝硬化代偿期患者17例、失代偿期32例、肝硬化失代偿期合并自发性腹膜炎13例,共计62例;分别测定其静脉血血浆中IL-8、IL-12和TNF-α含量。检测采用ELISA方法。分析细胞因子在不同时期的肝硬化及不同肝功能状况的关系。结果细胞因子IL-8、IL-12和TNF-α在各组肝硬化患者均有不同程度的升高。且升高的程度与肝硬化患者病情的严重程度相一致。结论细胞因子升高的幅度与Child-Pugh分级标准评估的肝功能严重程度成正比。
Objective To investigate the relationship between changes of cytokines IL-8, IL-12 and TNF-α related to liver damage in cirrhosis and different liver functions in different periods in order to clarify the clinical significance of detection of cytokines in decompensation of liver cirrhosis And part of the mechanism. Methods 17 patients with decompensated cirrhosis, 32 decompensated patients, 13 patients with decompensated liver cirrhosis and spontaneous peritonitis were enrolled in this study. A total of 62 patients were enrolled in this study. The levels of IL-8, IL-12 And TNF-α content. Detection using ELISA method. Analysis of cytokines in different stages of cirrhosis and different liver function status. Results The cytokines IL-8, IL-12 and TNF-α in patients with cirrhosis were all increased to some extent. And the extent of the increase is consistent with the severity of the disease in patients with cirrhosis. Conclusions The magnitude of the increase in cytokines is directly proportional to the severity of liver function as assessed by the Child-Pugh criteria.