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[目的]探讨重型颅脑损伤患者早期应用肠内营养后免疫功能的变化。[方法]对100例重型颅脑损伤病人(格拉斯哥昏迷评分≤8分)随机分为肠内营养组(EN组)采用十二指肠置管进行早期肠内营养50例和肠外营养组(PN组)50例。用流式细胞仪检测患者外周静脉血Th1、Th2细胞含量、Th1/Th2,ELISA法测定IL-2、IL-6含量,对比研究两组的免疫功能变化。[结果]重型颅脑损伤后病人免疫功能明显下降,而EN组患者血清中的Th1、Th2细胞含量、Th1/Th2显著高于PN组(P﹤0.01),IL-2、IL-6明显高于PN组(P﹤0.05)。[结论]重型颅脑损伤病人可导致机体免疫功能下降,早期肠内营养支持可提高人体免疫功能,减少并发症。
[Objective] To explore the changes of immune function in early stage of severe craniocerebral injury patients after enteral nutrition. [Methods] 100 patients with severe traumatic brain injury (Glasgow coma score≤8) were randomly divided into enteral nutrition group (EN group), duodenal catheterization for early enteral nutrition (50 cases) and parenteral nutrition group PN group) 50 cases. The levels of Th1 and Th2 in peripheral venous blood and Th1 / Th2 were detected by flow cytometry. The levels of IL-2 and IL-6 were measured by ELISA. The immune function of the two groups were compared. [Results] The immune function of patients with severe traumatic brain injury was significantly decreased. The levels of Th1 and Th2, Th1 / Th2 in serum of EN group were significantly higher than those in PN group (P <0.01), while IL-2 and IL-6 were significantly higher In PN group (P <0.05). [Conclusion] Patients with severe craniocerebral injury may lead to the decline of immune function. Early enteral nutrition support can improve the immune function and reduce the complications.