Objective To investigate the effects of high concentrations of iodide exposure on mitochondrial superoxide production,cell viability and cell damage in the thyroid of metallothioneinⅠ/Ⅱknockout(MT-Ⅰ/ⅡKO)mice and corresponding wild type(WT)mice.Methods Thyroid cell suspension of six to eight weeks old healthy male MT-Ⅰ/ⅡKO mice and WT mice were prepared.The Objective To investigate the effects of high concentrations of iodide exposure on mitochondrial superoxide production, cell viability and cell damage in the thyroid of metallothionein I / II knockout (MT-I / II KO) mice and corresponding wild type (WT) mice. Methods Thyroid cell suspension of Six to eight weeks old healthy male MT-I / IIKO mice and WT mice were prepared