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本试验目的在于评价氧氟沙星葡萄糖注射液治疗下呼吸道感染的临床有有效性及不良反应,选用头孢唑啉钠作对照治疗。方法:将入选患者随机分为氧氟沙星葡萄糖注射液治疗组26例,对照组26例。给药方法:氧氟沙星葡萄糖注射液每次100ml(含氧氟沙星0.2g),头孢唑啉钠每次2.0g溶于5％葡萄糖液100ml中,分别为每日2次静脉点滴,疗程均为7～14天。结果:氧氟沙星治疗组治愈15例,显效9例,有效率为92％;对照组治愈10例,显效7例,有效率为65％,显示两药疗效有显著性差异P<0.05。治疗结束后两组细菌清除率分别为96％与68％,两药有非常显著性差异P<0.01。不良反应发生率分别为4％与15.38％,无显著性差异P>0.05。结论:观察表明氧氟沙星葡萄糖注射液对下呼吸道感染较头孢唑啉钠抗细菌感染作用强,无明显不良反应,提倡优选使用。
The purpose of this test is to evaluate the clinical effectiveness of ofloxacin and glucose injection in the treatment of lower respiratory tract infections and adverse reactions, the choice of cefazolin sodium for the control treatment. Methods: The patients were randomly divided into ofloxacin glucose injection treatment group of 26 patients, control group of 26 patients. Administration: Ofloxacin glucose injection 100ml each (ofloxacin 0.2g), cefazolin sodium each 2.0g dissolved in 5% glucose solution 100ml, respectively, 2 times daily intravenous drip, Treatment are 7 to 14 days. Results: Ofloxacin group were cured in 15 cases, markedly effective in 9 cases, the effective rate was 92%; the control group cured 10 cases, markedly effective in 7 cases, the effective rate was 65%, showed significant difference between the two drugs P <0.05. After the treatment, the bacterial clearance rates of the two groups were 96% and 68% respectively, with significant difference between the two groups (P <0.01). Adverse reaction rates were 4% and 15.38%, no significant difference P> 0.05. Conclusion: It is observed that ofloxacin and glucose injection has lower anti-bacterial infection to lower respiratory tract infection than cefazolin sodium, no obvious adverse reactions, and the promotion of optimal use.