论文部分内容阅读
目的探讨浙江省百日咳流行病学特征,为制定有效控制策略提供科学依据。方法采用描述流行病学分析方法。结果浙江省百日咳发病分为3个阶段:未使用疫苗时期的1954~1959年,年平均报告发病率为212.67/10万;使用疫苗初期的1960~1984年,年平均报告发病率为102.17/10万;实施计划免疫时期的1985~2004年,特别是1988年起全省推广使用吸附全细胞百白破联合疫苗(DTwP),发病明显下降,1994年以来报告发病率<1/10万。对DTwP免疫成功率监测表明,免疫后百日咳凝集抗体达到保护水平(≥1∶320)者>90%,几何平均滴度免疫后比免疫前增长29.4~210.5倍。结论目前浙江省百日咳的年平均报告发病率<0.5/10万。有效的DTwP疫苗和高质量的全程免疫接种率,加强疫情和人群免疫水平监测,是控制百日咳的重要策略。
Objective To investigate the epidemiological characteristics of pertussis in Zhejiang Province and provide a scientific basis for making effective control strategy. Methods Describe methods of epidemiological analysis. Results The incidence of pertussis in Zhejiang Province was divided into three stages: the unused vaccine period from 1954 to 1959, the annual average reported incidence of 212.67 / 100000; the initial use of vaccines from 1960 to 1984, the annual average reported incidence of 102.17 / 10 In the period from 1985 to 2004, especially since 1988, there was a marked decrease in the incidence of DTwP, which has been reported since 1994 in China. The reported incidence rate was <1/10 million since 1994. The monitoring of the success rate of DTwP immunization showed that after the immunization, pertussis agglutination antibody reached the level of protection (≥1: 320)> 90%, and the geometric mean titer increased by 29.4-210.5 times than before immunization. Conclusions At present, the annual average incidence of whooping cough in Zhejiang Province is less than 0.5 / 100000. Effective DTwP vaccine and high-quality whole-course immunization rate, strengthen the epidemic and crowd immunity monitoring, is an important strategy to control whooping cough.