论文部分内容阅读
目的 观察硫普罗宁对慢性乙型肝炎氧自由基的清除作用。方法 用黄嘌呤氧化酶法对 80例慢性乙型肝炎体内的超氧化物歧化酶 (SOD)进行检测 ,并检测了丙氨酸转氨酶 (ALT)、血清总胆红素 (TBiL)、血清总蛋白 (TP)、A G比值。 40例接受常规护肝 ,退黄治疗为对照组 ;40例除接受护肝、退黄治疗外 ,口服硫普罗宁为治疗组。结果 16例正常人SOD活性检测正常值为 16 5 .9±2 3 .36NU ml。 40例治疗组与 40例对照组治疗前年龄、性别无差异 ,SOD、ALT、TBil、TP、ALB亦无差异 ,SOD分别为 10 6 .5 7± 40 .6 8与 10 5 .18± 44 .5 9。两组治疗后 ,SOD、ALT、TBil、ALB的测定值差异有显著性 (P <0 .0 1) ,SOD分别为 187.93± 35 .2 4与 15 7.96± 47.2 9;ALT分别为 38.41± 2 2 .2 2与6 8.5 2± 34.19;TBil分别为 2 3 .15± 12 .46与 30 .38± 2 1.80 ;ALB分别为 43.2 8± 4.2 1与 40 .36± 5 .19。结论 硫普罗宁对治疗慢性乙型肝炎、清除氧自由基有较好疗效 ,且有改善肝功能的作用
Objective To observe the scavenging effect of tiopronin on oxygen free radicals in chronic hepatitis B Methods The superoxide dismutase (SOD) in 80 patients with chronic hepatitis B was detected by xanthine oxidase method. The levels of alanine aminotransferase (ALT), serum total bilirubin (TBiL), total serum protein (TP), AG ratio. Forty patients underwent routine liver protection and yellowing treatment as the control group. Forty patients received oral administration of tiopronin, except for liver protection and yellowing treatment. Results The normal SOD activity of 16 healthy people was 16.59 ± 2.36 NUNU. 40 cases of treatment group and 40 cases of control group before treatment, no difference in age, sex, SOD, ALT, TBil, TP, ALB also no difference, SOD were 106.57 ± 40.68 and 105.18 ± 44 .5 9. After treatment, the differences of SOD, ALT, TBil and ALB between the two groups were significant (P <0.01), and the SOD were 187.93 ± 35.24 and 15 7.96 ± 47.29 respectively; the ALT were 38.41 ± 2 2 .2 2 and 6 8.5 2 ± 34.19; TBil was 23.15 ± 12.46 and 30 .38 ± 2 1.80 respectively; ALB was 43.2 8 ± 4.2 1 and 40 .36 ± 5 .19, respectively. Conclusion Tiopronin is effective in treating chronic hepatitis B and scavenging oxygen free radicals and has the effect of improving liver function