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目的：观察疏肝解郁胶囊联合帕罗西汀治疗首发抑郁症的效果及不良反应。方法将首发抑郁症患者60例随机分为观察组及对照组各30例。观察组采用疏肝解郁胶囊联合帕罗西汀治疗,对照组采用帕罗西汀治疗。对比2组治疗2、4、8周汉密尔顿抑郁量表( HAMD)评分和疗效及不良反应。结果治疗前2组HAMD评分比较差异无统计学意义(P>0.05)。治疗后,观察组HAMD评分在第2周开始下降,对照组HAMD评分在第4周末开始下降。第2、4、8周,2组间差异有统计学意义(P0. 05). After treatment,the HAMD in observation group scores began to decline in the first two weeks,HAMD score in the control group began to decrease in the first four weeks. The HAMD score in two groups during 2,4,8 weeks was statistically significant difference(P<0. 05). The recovery rate and effective rate of observa-tion group at 4th week,8th week after the treatment were higher than that of control group,the differences were statistically sig-nificant(P0. 05). Conclusion Shu-ganjieyu capsule combined with paroxetine in treatment of first-episode depression is more effectively than paroxetine used on-ly,and has a high clinic recovery rate and few side effects.